Involvement of GPR50 polymorphisms in depression: independent replication in a prospective elderly cohort.

ABSTRACT:

Introduction

Despite the explosion in genetic association studies over the last decade, clearly identified genetic risk factors for depression remain scarce and replication studies are becoming increasingly important. G-protein-coupled receptor 50 (GPR50) has been implicated in psychiatric disorders in a small number of studies, although not consistently.

Methods

Data were obtained from 1010 elderly men and women from the prospective population-based ESPRIT study. Logistic regression and survival models were used to determine whether three common GPR50 polymorphisms were associated with depression prevalence or the incidence of depression over 12-years. The analyses were adjusted for a range of covariates such as comorbidity and cholesterol levels, to determine independent a

SUBMITTER: Ryan J 

PROVIDER: S-EPMC4356842 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature