Ontology highlight
ABSTRACT:
SUBMITTER: Vidal SJ
PROVIDER: S-EPMC4356948 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Vidal Samuel J SJ Rodriguez-Bravo Veronica V Quinn S Aidan SA Rodriguez-Barrueco Ruth R Lujambio Amaia A Williams Estrelania E Sun Xiaochen X de la Iglesia-Vicente Janis J Lee Albert A Readhead Ben B Chen Xintong X Galsky Matthew M Esteve Berta B Petrylak Daniel P DP Dudley Joel T JT Rabadan Raul R Silva Jose M JM Hoshida Yujin Y Lowe Scott W SW Cordon-Cardo Carlos C Domingo-Domenech Josep J
Cancer cell 20150201 2
Elucidating the determinants of aggressiveness in lethal prostate cancer may stimulate therapeutic strategies that improve clinical outcomes. We used experimental models and clinical databases to identify GATA2 as a regulator of chemotherapy resistance and tumorigenicity in this context. Mechanistically, direct upregulation of the growth hormone IGF2 emerged as a mediator of the aggressive properties regulated by GATA2. IGF2 in turn activated IGF1R and INSR as well as a downstream polykinase pro ...[more]