Ontology highlight
ABSTRACT:
SUBMITTER: Nistico R
PROVIDER: S-EPMC4357012 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Scientific reports 20150312
Activation of c-Jun N-terminal kinase (JNK) signaling pathway is a critical step for neuronal death occurring in several neurological conditions. JNKs can be activated via receptor tyrosine kinases, cytokine receptors, G-protein coupled receptors and ligand-gated ion channels, including the NMDA glutamate receptors. While JNK has been generally associated with postsynaptic NMDA receptors, its presynaptic role remains largely unexplored. Here, by means of biochemical, morphological and functional ...[more]