A permutation test for oligoset DNA pooling studies.
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ABSTRACT:
SUBMITTER: Huang HY
PROVIDER: S-EPMC4357378 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
A permutation test for oligoset DNA pooling studies.
Huang Hsiao-Yuan HY Lin Jui-Hsiang JH Lee Wen-Chung WC
PloS one 20150312 3
Case-control association studies often suffer from population stratification bias. A previous triple combination strategy of stratum matching, genomic controlling, and multiple DNA pooling can correct the bias and save genotyping cost. However the method requires researchers to prepare a multitude of DNA pools-more than 30 case-control pooling sets in total (polyset). In this paper, the authors propose a permutation test for oligoset DNA pooling studies. Monte-Carlo simulations show that the pro ...[more]
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