Ontology highlight
ABSTRACT:
SUBMITTER: Barnett CF
PROVIDER: S-EPMC4357542 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Barnett Christopher F CF Moreno-Ulloa Aldo A Shiva Sruti S Ramirez-Sanchez Israel I Taub Pam R PR Su Yongxuan Y Ceballos Guillermo G Dugar Sundeep S Schreiner George G Villarreal Francisco F
Food & function 20150301 3
(-)-Epicatechin ((-)-EPI), a naturally occurring flavanol, has emerged as a likely candidate for cocoa-based product reported reductions in cardiometabolic risk. The present study aimed to determine the safety, tolerability, pharmacokinetics and pharmacodynamics of purified (-)-EPI administered to healthy volunteers. In this phase I, open-label, two-part single- and multiple-dose study, subjects received either a single dose (n = 9) of 50, 100 or 200 mg or multiple doses (n = 8) of 50 mg daily ( ...[more]