Ontology highlight
ABSTRACT:
SUBMITTER: Yu R
PROVIDER: S-EPMC4357591 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Molecular cell 20131226 2
Endogenous small interfering RNAs (siRNAs) and other classes of small RNA provide the specificity signals for silencing of transposons and repeated DNA elements at the posttranscriptional and transcriptional levels. However, the determinants that define an siRNA-producing region or control the silencing function of siRNAs are poorly understood. Here we show that convergent antisense transcription and availability of the Dicer ribonuclease are the key determinants for primary siRNA generation. Su ...[more]