Ontology highlight
ABSTRACT:
SUBMITTER: Sansam CG
PROVIDER: S-EPMC4358407 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Sansam Courtney G CG Goins Duane D Siefert Joseph C JC Clowdus Emily A EA Sansam Christopher L CL
Genes & development 20150301 5
S-phase cyclin-dependent kinases (CDKs) stimulate replication initiation and accelerate progression through the replication timing program, but it is unknown which CDK substrates are responsible for these effects. CDK phosphorylation of the replication factor TICRR (TopBP1-interacting checkpoint and replication regulator)/TRESLIN is required for DNA replication. We show here that phosphorylated TICRR is limiting for S-phase progression. Overexpression of a TICRR mutant with phosphomimetic mutati ...[more]