Ontology highlight
ABSTRACT:
SUBMITTER: Yu M
PROVIDER: S-EPMC4358808 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20140701 6193
Circulating tumor cells (CTCs) are present at low concentrations in the peripheral blood of patients with solid tumors. It has been proposed that the isolation, ex vivo culture, and characterization of CTCs may provide an opportunity to noninvasively monitor the changing patterns of drug susceptibility in individual patients as their tumors acquire new mutations. In a proof-of-concept study, we established CTC cultures from six patients with estrogen receptor-positive breast cancer. Three of fiv ...[more]