Ontology highlight
ABSTRACT:
SUBMITTER: Kim YU
PROVIDER: S-EPMC4358919 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Kim Young Uk YU Lim Hoyong H Jung Ha Eun HE Wetsel Rick A RA Chung Yeonseok Y
PloS one 20150313 3
BXD2 mice spontaneously develop autoantibodies and subsequent glomerulonephritis, offering a useful animal model to study autoimmune lupus. Although initial studies showed a critical contribution of IL-17 and Th17 cells in mediating autoimmune B cell responses in BXD2 mice, the role of follicular helper T (Tfh) cells remains incompletely understood. We found that both the frequency of Th17 cells and the levels of IL-17 in circulation in BXD2 mice were comparable to those of wild-type. By contras ...[more]