Ontology highlight
ABSTRACT:
SUBMITTER: Rosa A
PROVIDER: S-EPMC4359025 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Developmental cell 20150219 5
Entry into mitosis is accompanied by profound changes in cortical actomyosin organization. Here, we delineate a pathway downstream of the RhoGEF Pbl/Ect2 that directs this process in a model epithelium. Our data suggest that the release of Pbl/Ect2 from the nucleus at mitotic entry drives Rho-dependent activation of Myosin-II and, in parallel, induces a switch from Arp2/3 to Diaphanous-mediated cortical actin nucleation that depends on Cdc42, aPKC, and Par6. At the same time, the mitotic relocal ...[more]