Ontology highlight
ABSTRACT:
SUBMITTER: Munoz JL
PROVIDER: S-EPMC4359226 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Munoz Jessian L JL Rodriguez-Cruz Vivian V Ramkissoon Shakti H SH Ligon Keith L KL Greco Steven J SJ Rameshwar Pranela P
Oncotarget 20150101 2
Glioblastoma Multiforme (GBM), the most common and lethal adult primary tumor of the brain, showed a link between Sonic Hedgehog (SHH) pathway in the resistance to temozolomide (TMZ). PTCH1, the SHH receptor, can tonically represses signaling by endocytosis. We asked how the decrease in PTCH1 in GBM cells could lead to TMZ-resistance. TMZ resistant GBM cells have increased PTCH1 mRNA and reduced protein. Knockdown of Dicer, a Type III RNAase, indicated that miRNAs can explain the decreased PTCH1 ...[more]