Ontology highlight
ABSTRACT:
SUBMITTER: Taylor-Harding B
PROVIDER: S-EPMC4359249 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Taylor-Harding Barbie B Aspuria Paul-Joseph PJ Agadjanian Hasmik H Cheon Dong-Joo DJ Mizuno Takako T Greenberg Danielle D Allen Jenieke R JR Spurka Lindsay L Funari Vincent V Spiteri Elizabeth E Wang Qiang Q Orsulic Sandra S Walsh Christine C Karlan Beth Y BY Wiedemeyer W Ruprecht WR
Oncotarget 20150101 2
High-grade serous ovarian cancers (HGSOC) are genomically complex, heterogeneous cancers with a high mortality rate, due to acquired chemoresistance and lack of targeted therapy options. Cyclin-dependent kinase inhibitors (CDKi) target the retinoblastoma (RB) signaling network, and have been successfully incorporated into treatment regimens for breast and other cancers. Here, we have compared mechanisms of response and resistance to three CDKi that target either CDK4/6 or CDK2 and abrogate E2F t ...[more]