Ontology highlight
ABSTRACT:
SUBMITTER: Xu M
PROVIDER: S-EPMC4359269 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Xu Ming M Zhu Changhong C Zhao Xian X Chen Cheng C Zhang Hailong H Yuan Haihua H Deng Rong R Dou Jinzhuo J Wang Yanli Y Huang Jian J Chen Qin Q Jiang Bin B Yu Jianxiu J
Oncotarget 20150101 2
Epithelial-mesenchymal transition (EMT) plays a critical role in the development of tumor metastases by enhancing migration/invasion. One of the hallmarks of EMT is loss of E-cadherin and gain of N-cadherin expression, which are regulated by the core EMT-inducing transcription factors (EMT-TFs), such as Zeb1/2, Snai1/2 and Twist1. Here, we find that EMT-TFs can be dynamically degraded by an atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 (SPFFbxo45) through the ubiquitin proteasome system ( ...[more]