Ontology highlight
ABSTRACT:
SUBMITTER: Bhardwaj V
PROVIDER: S-EPMC4359312 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Bhardwaj Vikas V Noto Jennifer M JM Wei Jinxiong J Andl Claudia C El-Rifai Wael W Peek Richard M RM Zaika Alexander I AI
Oncotarget 20150101 3
H. pylori infection is the strongest known risk factor for gastric cancer. Inhibition of host tumor suppressor mechanisms by the bacteria underlies the development of this disease. Among the tumor suppressors affected by H. pylori are p53 and E-cadherin, which inhibition has been shown to increase the risk of gastric cancer. In this report, we investigated the interaction between E-cadherin and p53 in H. pylori-infected cells. We found that downregulation of E-cadherin leads to cellular stress a ...[more]