Ontology highlight
ABSTRACT:
SUBMITTER: Chatterjee D
PROVIDER: S-EPMC4359373 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Chatterjee Debashree D Cooley Richard B RB Boyd Chelsea D CD Mehl Ryan A RA O'Toole George A GA Sondermann Holger H
eLife 20140902
Stable surface adhesion of cells is one of the early pivotal steps in bacterial biofilm formation, a prevalent adaptation strategy in response to changing environments. In Pseudomonas fluorescens, this process is regulated by the Lap system and the second messenger cyclic-di-GMP. High cytoplasmic levels of cyclic-di-GMP activate the transmembrane receptor LapD that in turn recruits the periplasmic protease LapG, preventing it from cleaving a cell surface-bound adhesin, thereby promoting cell adh ...[more]