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Center for International Blood and Marrow Transplant Research chronic graft-versus-host disease risk score predicts mortality in an independent validation cohort.


ABSTRACT: We previously reported a risk score that predicted mortality in patients with chronic graft-versus-host disease (CGVHD) after hematopoietic stem cell transplantation (HCT) between 1995 and 2004 and reported to the Center for International Blood and Marrow Transplant Research (CIBMTR). We sought to validate this risk score in an independent CIBMTR cohort of 1128 patients with CGVHD who underwent transplantation between 2005 and 2007 using the same inclusion criteria and risk score calculations. According to the sum of the overall risk score (range, 1 to 12), patients were assigned to 4 risk groups (RGs): RG1 (0 to 2), RG2 (3 to 6), RG3 (7 to 8), and RG4 (9 to 10). RG3 and RG4 were combined, as RG4 accounted for only 1% of the total cohort. Cumulative incidences of nonrelapse mortality (NRM) and probability of overall survival were significantly different between each RG (all P < .01). NRM and overall survival at 5 years after CGVHD for each RG were 17% and 72% in RG1, 26% and 53% in RG2, and 44% and 25% in RG3, respectively (all P < .01). Our study validates the prognostic value of the CIBMTR CGVHD RGs for overall survival and NRM in a contemporary transplantation population. The CIBMTR CGVHD RGs can be used to predict major outcomes, tailor treatment planning, and enroll patients in clinical trials.

SUBMITTER: Arora M 

PROVIDER: S-EPMC4359642 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Center for International Blood and Marrow Transplant Research chronic graft-versus-host disease risk score predicts mortality in an independent validation cohort.

Arora Mukta M   Hemmer Michael T MT   Ahn Kwang Woo KW   Klein John P JP   Cutler Corey S CS   Urbano-Ispizua Alvaro A   Couriel Daniel R DR   Alousi Amin M AM   Gale Robert Peter RP   Inamoto Yoshihiro Y   Weisdorf Daniel J DJ   Li Peigang P   Antin Joseph H JH   Bolwell Brian J BJ   Boyiadzis Michael M   Cahn Jean-Yves JY   Cairo Mitchell S MS   Isola Luis M LM   Jacobsohn David A DA   Jagasia Madan M   Klumpp Thomas R TR   Petersdorf Effie W EW   Santarone Stella S   Schouten Harry C HC   Wingard John R JR   Spellman Stephen R SR   Pavletic Steven Z SZ   Lee Stephanie J SJ   Horowitz Mary M MM   Flowers Mary E D ME  

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20141218 4


We previously reported a risk score that predicted mortality in patients with chronic graft-versus-host disease (CGVHD) after hematopoietic stem cell transplantation (HCT) between 1995 and 2004 and reported to the Center for International Blood and Marrow Transplant Research (CIBMTR). We sought to validate this risk score in an independent CIBMTR cohort of 1128 patients with CGVHD who underwent transplantation between 2005 and 2007 using the same inclusion criteria and risk score calculations. A  ...[more]

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