Ontology highlight
ABSTRACT: Background
Increasing number of cases with small supernumerary marker chromosomes (sSMCs) without centromeric DNA and dozens of cases with trisomy 2q3 have been reported in recent years. However, cases of simultaneous sSMC and partial trisomy of chromosome 2q have been rarely described.Results
We report the case of a young girl patient with growth retardation and mild facial features due to a partial trisomy 2q33.3-37.3. The 34.3 Mb-duplication of the 2q33.3 to q37.3 region found in the patient constituted a supernumerary inverted duplicated neocentric marker chromosome.Conclusions
This is the first case of a patient with partial trisomy 2q33.3-37.3 presenting an inverted duplicated neocentric marker chromosome. Based on the case, this study will help further understanding the genotype/phenotype correlations of partial 2q3 duplication and exploring the relationship between neocentric sSMC and human diseases.
SUBMITTER: Ma R
PROVIDER: S-EPMC4359772 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Ma Ruiyu R Peng Ying Y Zhang Yanghui Y Xia Yan Y Tang Guizhi G Chang Jiazhen J Guo Ruolan R Gui Baoheng B Huang Yanru Y Chen Chen C Liang Desheng D Wu Lingqian L
Molecular cytogenetics 20150206
<h4>Background</h4>Increasing number of cases with small supernumerary marker chromosomes (sSMCs) without centromeric DNA and dozens of cases with trisomy 2q3 have been reported in recent years. However, cases of simultaneous sSMC and partial trisomy of chromosome 2q have been rarely described.<h4>Results</h4>We report the case of a young girl patient with growth retardation and mild facial features due to a partial trisomy 2q33.3-37.3. The 34.3 Mb-duplication of the 2q33.3 to q37.3 region found ...[more]