Kruppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells.
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ABSTRACT:
SUBMITTER: Wang B
PROVIDER: S-EPMC4359971 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Krüppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells.
Wang Bing B Zhao Ming-Zhi MZ Cui Nai-Peng NP Lin Dan-Dan DD Zhang An-Yi AY Qin Yan Y Liu Cai-Yun CY Yan Wei-Tao WT Shi Jian-Hong JH Chen Bao-Ping BP
FEBS open bio 20150302
Krüppel-like factor 4 (KLF4) functions as either a tumor suppressor or an oncogene in different tissues by regulating the expression of various genes. The aim of this study was to reveal the functions of KLF4 in regulating breast cancer apoptosis, proliferation, and tumorigenic progression. KLF4 expression levels in breast cancer tissues and breast cancer cell lines were found to be much lower than those in nontumorous tissues and a nontransformed mammary epithelial cell line. KLF4 was upregulat ...[more]
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