Ontology highlight
ABSTRACT:
SUBMITTER: Moding EJ
PROVIDER: S-EPMC4360135 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Moding Everett J EJ Castle Katherine D KD Perez Bradford A BA Oh Patrick P Min Hooney D HD Norris Hannah H Ma Yan Y Cardona Diana M DM Lee Chang-Lung CL Kirsch David G DG
Science translational medicine 20150301 278
Cancer clinics currently use high-dose stereotactic body radiation therapy as a curative treatment for several kinds of cancers. However, the contribution of vascular endothelial cells to tumor response to radiation remains controversial. Using dual recombinase technology, we generated primary sarcomas in mice with targeted genetic mutations specifically in tumor cells or endothelial cells. We selectively mutated the proapoptotic gene Bax or the DNA damage response gene Atm to genetically manipu ...[more]