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Phenolic diterpenoid derivatives as anti-influenza a virus agents.

ABSTRACT: A series of diterpenoid derivatives based on podocarpic acid were synthesized and evaluated as anti-influenza A virus agents. Several of the novel podocarpic acid derivatives exhibited nanomolar activities against an H1N1 influenza A virus (A/Puerto Rico/8/34) that was resistant to two anti-influenza drugs, oseltamivir and amantadine. This class of compounds inhibits the influenza virus by targeting the viral hemagglutinin-mediated membrane fusion. These results indicated that podocarpic acid derivatives may serve as potential drug candidates to fight drug-resistant influenza A virus infections.

SUBMITTER: Dang Z

PROVIDER: S-EPMC4360168 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Phenolic diterpenoid derivatives as anti-influenza a virus agents.

Dang Zhao Z Jung Katherine K Zhu Lei L Xie Hua H Lee Kuo-Hsiung KH Chen Chin-Ho CH Huang Li L

ACS medicinal chemistry letters 20150129 3

A series of diterpenoid derivatives based on podocarpic acid were synthesized and evaluated as anti-influenza A virus agents. Several of the novel podocarpic acid derivatives exhibited nanomolar activities against an H1N1 influenza A virus (A/Puerto Rico/8/34) that was resistant to two anti-influenza drugs, oseltamivir and amantadine. This class of compounds inhibits the influenza virus by targeting the viral hemagglutinin-mediated membrane fusion. These results indicated that podocarpic acid de ...[more]

PMID: 25815159

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