Ontology highlight
ABSTRACT:
SUBMITTER: Singh I
PROVIDER: S-EPMC4360669 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Singh I I Nagiec E E EE Thompson J M JM Krzyzanski W W Singh P P
CPT: pharmacometrics & systems pharmacology 20150211 2
Mammalian erythropoiesis is a conserved process tightly controlled by the hypoxia-inducible factor (HIF1) pathway. In this study, a small molecule inhibitor (PHI-1) of prolyl-hydroxylase-2 (PHD2) enzyme involved in regulating HIF1α levels was orally administered to male BALB/c mice at 10 and 30 mg/kg. A systems pharmacology model was developed based on the measured PHI-1 plasma exposures, kidney HIF1α, kidney erythropoietin (EPO) mRNA, plasma EPO, reticulocyte counts, red blood cells, and hemogl ...[more]