Ontology highlight
ABSTRACT:
SUBMITTER: Schreiner B
PROVIDER: S-EPMC4361052 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Schreiner Bettina B Ingold-Heppner Barbara B Pehl Debora D Locatelli Giuseppe G Berrit-Schönthaler Helia H Becher Burkhard B
PloS one 20150316 3
Oligodendrocytes, the myelin-forming glial cells of the central nervous system (CNS), are fundamental players in rapid impulse conduction and normal axonal functions. JunB and c-Jun are DNA-binding components of the AP-1 transcription factor, which is known to regulate different processes such as proliferation, differentiation, stress responses and death in several cell types, including cultured oligodendrocyte/lineage cells. By selectively inactivating Jun B and c-Jun in myelinating oligodendro ...[more]