Volitional modulation of optically recorded calcium signals during neuroprosthetic learning.
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ABSTRACT:
SUBMITTER: Clancy KB
PROVIDER: S-EPMC4361947 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Volitional modulation of optically recorded calcium signals during neuroprosthetic learning.
Clancy Kelly B KB Koralek Aaron C AC Costa Rui M RM Feldman Daniel E DE Carmena Jose M JM
Nature neuroscience 20140413 6
Brain-machine interfaces are not only promising for neurological applications, but also powerful for investigating neuronal ensemble dynamics during learning. We trained mice to operantly control an auditory cursor using spike-related calcium signals recorded with two-photon imaging in motor and somatosensory cortex. Mice rapidly learned to modulate activity in layer 2/3 neurons, evident both across and within sessions. Learning was accompanied by modifications of firing correlations in spatiall ...[more]
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