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Volitional modulation of optically recorded calcium signals during neuroprosthetic learning.


ABSTRACT: Brain-machine interfaces are not only promising for neurological applications, but also powerful for investigating neuronal ensemble dynamics during learning. We trained mice to operantly control an auditory cursor using spike-related calcium signals recorded with two-photon imaging in motor and somatosensory cortex. Mice rapidly learned to modulate activity in layer 2/3 neurons, evident both across and within sessions. Learning was accompanied by modifications of firing correlations in spatially localized networks at fine scales.

SUBMITTER: Clancy KB 

PROVIDER: S-EPMC4361947 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Volitional modulation of optically recorded calcium signals during neuroprosthetic learning.

Clancy Kelly B KB   Koralek Aaron C AC   Costa Rui M RM   Feldman Daniel E DE   Carmena Jose M JM  

Nature neuroscience 20140413 6


Brain-machine interfaces are not only promising for neurological applications, but also powerful for investigating neuronal ensemble dynamics during learning. We trained mice to operantly control an auditory cursor using spike-related calcium signals recorded with two-photon imaging in motor and somatosensory cortex. Mice rapidly learned to modulate activity in layer 2/3 neurons, evident both across and within sessions. Learning was accompanied by modifications of firing correlations in spatiall  ...[more]

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