Ontology highlight
ABSTRACT:
SUBMITTER: Zhu X
PROVIDER: S-EPMC4362239 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Zhu Xiaorong X Messer Jeannette S JS Wang Yunwei Y Lin Fanfei F Cham Candace M CM Chang Jonathan J Billiar Timothy R TR Lotze Michael T MT Boone David L DL Chang Eugene B EB
The Journal of clinical investigation 20150202 3
The intracellular protein HMGB1 is released from cells and acts as a damage-associated molecular pattern molecule during many diseases, including inflammatory bowel disease (IBD); however, the intracellular function of HMGB1 during inflammation is poorly understood. Here, we demonstrated that cytosolic HMGB1 regulates apoptosis by protecting the autophagy proteins beclin 1 and ATG5 from calpain-mediated cleavage during inflammation. Colitis in mice with an intestinal epithelial cell-specific Hmg ...[more]