Ontology highlight
ABSTRACT:
SUBMITTER: Qin L
PROVIDER: S-EPMC4362693 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20150122 6226
Chemokines and their receptors control cell migration during development, immune system responses, and in numerous diseases, including inflammation and cancer. The structural basis of receptor:chemokine recognition has been a long-standing unanswered question due to the challenges of structure determination for membrane protein complexes. Here, we report the crystal structure of the chemokine receptor CXCR4 in complex with the viral chemokine antagonist vMIP-II at 3.1 angstrom resolution. The st ...[more]