Ontology highlight
ABSTRACT:
SUBMITTER: Swanson CR
PROVIDER: S-EPMC4362847 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Swanson Christine R CR Li Katherine K Unger Travis L TL Gallagher Michael D MD Van Deerlin Vivianna M VM Agarwal Pinky P Leverenz James J Roberts John J Samii Ali A Gross Rachel Goldmann RG Hurtig Howard H Rick Jacqueline J Weintraub Daniel D Trojanowski John Q JQ Zabetian Cyrus C Chen-Plotkin Alice S AS
Movement disorders : official journal of the Movement Disorder Society 20140916 6
The discovery of novel plasma-based biomarkers could lead to new approaches in the treatment of Parkinson's disease (PD). Here, we explore the role of plasma apolipoprotein A1 (ApoA1) as a risk marker for PD and evaluate the influence of APOA1 promoter variation on plasma ApoA1 levels. Plasma ApoA1 and the single-nucleotide polymorphism, rs670, were assayed in a discovery cohort (cohort 1) of 301 PD patients, 80 normal controls (NCs), and 165 subjects with other neurodegenerative diseases, as we ...[more]