Ontology highlight
ABSTRACT:
SUBMITTER: Weaver D
PROVIDER: S-EPMC4363113 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Weaver David D Eisner Verónica V Liu Xingguo X Várnai Péter P Hunyady László L Gross Atan A Hajnóczky György G
Molecular cell 20140508 5
Cells deficient in mitochondrial fusion have been shown to have defects linked to the exchange of inner membrane and matrix components. Because outer-mitochondrial membrane (OMM) constituents insert directly from the cytoplasm, a role for fusion in their intermitochondrial transfer was unanticipated. Here, we show that fibroblasts lacking the GTPases responsible for OMM fusion, mitofusins 1 and 2 (MFN1 and MFN2), display more heterogeneous distribution of OMM proteins. Proteins with different mo ...[more]