Gene network exploration of crosstalk between apoptosis and autophagy in chronic myelogenous leukemia.

ABSTRACT:

Background

Gene expression levels change to adapt the stress, such as starvation, toxin, and radiation. The changes are signals transmitted through molecular interactions, eventually leading to two cellular fates, apoptosis and autophagy. Due to genetic variations, the signals may not be effectively transmitted to modulate apoptotic and autophagic responses. Such aberrant modulation may lead to carcinogenesis and drug resistance. The balance between apoptosis and autophagy becomes very crucial in coping with the stress. Though there have been evidences illustrating the apoptosis-autophagy interplay, the underlying mechanism and the participation of the regulators including transcription factors (TFs) and microRNAs (miRNAs) remain unclear.

Results

Gene network is a graphical

SUBMITTER: Wang F 

PROVIDER: S-EPMC4363532 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature