Ontology highlight
ABSTRACT:
SUBMITTER: Hu X
PROVIDER: S-EPMC4363565 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Hu Xiang X Liu Yang Y Qin Chunxia C Pan Zhenyu Z Luo Jun J Yu Aixi A Cheng Zhen Z
Cancer letters 20131222 1
Very few studies have been reported the function of wild type IDH1 in tumor progress. Previously, we reported that IDH1 correlated with pathological grade and metastatic potential inversely in human osteosarcoma. Here, IDH1 was found lower expressed in osteosarcoma tissues than that of adjacent normal bone tissues. In addition, we observed in vitro anti-proliferation and pro-apoptosis effects of up-regulated IDH1 on osteosarcoma cell lines. The migration and invasion activity was also markedly r ...[more]