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Pharmacogenomics and herb-drug interactions: merge of future and tradition.


ABSTRACT: The worldwide using of herb products and the increasing potential herb-drug interaction issue has raised enthusiasm on discovering the underlying mechanisms. Previous review indicated that the interactions may be mediated by metabolism enzymes and transporters in pharmacokinetic pathways. On the other hand, an increasing number of studies found that genetic variations showed some influence on herb-drug interaction effects whereas these genetic factors did not draw much attention in history. We highlight that pharmacogenomics may involve the pharmacokinetic or pharmacodynamic pathways to affect herb-drug interaction. We are here to make an updated review focused on some common herb-drug interactions in association with genetic variations, with the aim to help safe use of herbal medicines in different individuals in the clinic.

SUBMITTER: Liu MZ 

PROVIDER: S-EPMC4363646 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Pharmacogenomics and herb-drug interactions: merge of future and tradition.

Liu Mou-Ze MZ   Zhang Yue-Li YL   Zeng Mei-Zi MZ   He Fa-Zhong FZ   Luo Zhi-Ying ZY   Luo Jian-Quan JQ   Wen Jia-Gen JG   Chen Xiao-Ping XP   Zhou Hong-Hao HH   Zhang Wei W  

Evidence-based complementary and alternative medicine : eCAM 20150302


The worldwide using of herb products and the increasing potential herb-drug interaction issue has raised enthusiasm on discovering the underlying mechanisms. Previous review indicated that the interactions may be mediated by metabolism enzymes and transporters in pharmacokinetic pathways. On the other hand, an increasing number of studies found that genetic variations showed some influence on herb-drug interaction effects whereas these genetic factors did not draw much attention in history. We h  ...[more]

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