Ontology highlight
ABSTRACT:
SUBMITTER: Ott C
PROVIDER: S-EPMC4363703 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Ott Christine C Dorsch Eva E Fraunholz Martin M Straub Sebastian S Kozjak-Pavlovic Vera V
PloS one 20150317 3
Mitochondrial inner membrane folds into cristae, which significantly increase its surface and are important for mitochondrial function. The stability of cristae depends on the mitochondrial contact site (MICOS) complex. In human mitochondria, the inner membrane MICOS complex interacts with the outer membrane sorting and assembly machinery (SAM) complex, to form the mitochondrial intermembrane space bridging complex (MIB). We have created knockdown cell lines of most of the MICOS and MIB componen ...[more]