Ontology highlight
ABSTRACT:
SUBMITTER: Kwak JY
PROVIDER: S-EPMC4363722 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Kwak Ju Yeon JY Ham Hyun Joo HJ Kim Cheol Min CM Hwang Eun Seong ES
Molecules and cells 20150119 3
Nicotinamide (NAM) has been shown to suppress reactive oxygen species (ROS) production in primary human fibroblasts, thereby extending their replicative lifespan when added to the medium during long-term cultivation. Based on this finding, NAM is hypothesized to affect cellular senescence progression by keeping ROS accumulation low. In the current study, we asked whether NAM is indeed able to reduce ROS levels and senescence phenotypes in cells undergoing senescence progression and those already ...[more]