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?-2-macroglobulin in saliva is associated with glycemic control in patients with type 2 diabetes mellitus.

ABSTRACT: Subjects with type 2 diabetes mellitus (DM2) require an adequate glycemic control to avoid diabetic complications. Currently, saliva biomarkers are used as a diagnostic tool and can be indicative of the degree of progression and control of various diseases. Several studies indicate that ?-2-macroglobulin levels are elevated in diabetic patients.120 subjects with DM2 were enrolled and classified into two groups according to their glycemic control (percentage of glycated hemoglobin-A1c (HbA1c), <7% adequate glycemic control group; >7% inadequate glycemic control group). The relationship between ?-2-macroglobulin levels from saliva samples and HbA1c was subsequently evaluated.We found a positive correlation between ?-2-macroglobulin and HbA1c (r = 0.778 and P < 0.0001). Area under the receivers operating characteristic (ROC) curve of ?-2-macroglobulin indicated a positive discrimination threshold of ?-2-macroglobulin (AUC = 0.903, CI 95%: 0.847-0.959, P < 0.0001) to diagnose glycemic control.Our data strongly suggest that the level of saliva ?-2-macroglobulin is an indicator for the degree of glycemic control in diabetic patients and represents a promising alternative method to evaluate this parameter.

SUBMITTER: Aitken JP

PROVIDER: S-EPMC4363888 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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α-2-macroglobulin in saliva is associated with glycemic control in patients with type 2 diabetes mellitus.

Aitken Juan Pablo JP Ortiz Carolina C Morales-Bozo Irene I Rojas-Alcayaga Gonzalo G Baeza Mauricio M Beltran Caroll C Escobar Alejandro A

Disease markers 20150303

<h4>Background</h4>Subjects with type 2 diabetes mellitus (DM2) require an adequate glycemic control to avoid diabetic complications. Currently, saliva biomarkers are used as a diagnostic tool and can be indicative of the degree of progression and control of various diseases. Several studies indicate that α-2-macroglobulin levels are elevated in diabetic patients.<h4>Methods</h4>120 subjects with DM2 were enrolled and classified into two groups according to their glycemic control (percentage of ...[more]

PMID: 25821337

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Project description:ObjectiveTo assess the rate of glycemic control and associated factors among type 2 diabetes mellitus patients at Dilchora Referral Hospital, Dire Dawa, Eastern Ethiopia.MethodsA cross-sectional study was conducted from 13 May to 16 August 2019. Type 2 diabetic patients on follow up at Dilchora Referral Hospital who fulfilled the inclusion criteria of the study were included. Systematic random sampling was used to select study participants. Data was collected by a face-to-face interview and review of medical records. The primary outcome was the level of blood glucose during three consecutive visits. Poor glycemic control was defined as a blood sugar level of more than 154 mg/dL based on the average of measurements from three consecutive visits. Multivariate logistic regression analysis was used to identify determinants of glycemic control.ResultA total of 394 participants responded to the interview and were included in the final analysis. The overall prevalence of poor glycemic control was 45.2% (95%CI: 40.6%-50.0%). Patients who were on oral anti-diabetic drug plus insulin had more than two times greater chance of poor glycemic control than patients on oral anti-diabetic drug alone: 2.177(95%CI:1.10-4.29). The odds of poor glycemic control in patients who did not understand the pharmacist's instructions was two times higher than patients with good understanding of instructions 1.86(95%CI: 1.10-3.13). Patients who had poor level of practice were found to have poor glycemic control: 1.69(95% CI: 1.13-2.55).ConclusionThe overall prevalence of poor glycemic control was high among type 2 diabetes patients. Oral anti-diabetic drugs in combination with insulin, lack of understanding of pharmacist's advice, and poor practice of diabetic patients were significant factors of poor glycemic control. Pharmacists should reassure the understanding of patients before discharge during counseling. Optimization of the dose of antidiabetic medications and combination of oral hypoglycemic agents should be considered.

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?-2-macroglobulin in saliva is associated with glycemic control in patients with type 2 diabetes mellitus.

Publications

α-2-macroglobulin in saliva is associated with glycemic control in patients with type 2 diabetes mellitus.

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