Ontology highlight
ABSTRACT: Background
Subjects with type 2 diabetes mellitus (DM2) require an adequate glycemic control to avoid diabetic complications. Currently, saliva biomarkers are used as a diagnostic tool and can be indicative of the degree of progression and control of various diseases. Several studies indicate that α-2-macroglobulin levels are elevated in diabetic patients.Methods
120 subjects with DM2 were enrolled and classified into two groups according to their glycemic control (percentage of glycated hemoglobin-A1c (HbA1c), <7% adequate glycemic control group; >7% inadequate glycemic control group). The relationship between α-2-macroglobulin levels from saliva samples and HbA1c was subsequently evaluated.Results
We found a positive correlation between α-2-macroglobulin and HbA1c (r = 0.778 and P < 0.0001). Area under the receivers operating characteristic (ROC) curve of α-2-macroglobulin indicated a positive discrimination threshold of α-2-macroglobulin (AUC = 0.903, CI 95%: 0.847-0.959, P < 0.0001) to diagnose glycemic control.Conclusions
Our data strongly suggest that the level of saliva α-2-macroglobulin is an indicator for the degree of glycemic control in diabetic patients and represents a promising alternative method to evaluate this parameter.
SUBMITTER: Aitken JP
PROVIDER: S-EPMC4363888 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Aitken Juan Pablo JP Ortiz Carolina C Morales-Bozo Irene I Rojas-Alcayaga Gonzalo G Baeza Mauricio M Beltran Caroll C Escobar Alejandro A
Disease markers 20150303
<h4>Background</h4>Subjects with type 2 diabetes mellitus (DM2) require an adequate glycemic control to avoid diabetic complications. Currently, saliva biomarkers are used as a diagnostic tool and can be indicative of the degree of progression and control of various diseases. Several studies indicate that α-2-macroglobulin levels are elevated in diabetic patients.<h4>Methods</h4>120 subjects with DM2 were enrolled and classified into two groups according to their glycemic control (percentage of ...[more]