Ontology highlight
ABSTRACT:
SUBMITTER: Krishnaswamy JK
PROVIDER: S-EPMC4364188 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Krishnaswamy Jayendra Kumar JK Singh Arpita A Gowthaman Uthaman U Wu Renee R Gorrepati Pavane P Sales Nascimento Manuela M Gallman Antonia A Liu Dong D Rhebergen Anne Marie AM Calabro Samuele S Xu Lan L Ranney Patricia P Srivastava Anuj A Ranson Matthew M Gorham James D JD McCaw Zachary Z Kleeberger Steven R SR Heinz Leonhard X LX Müller André C AC Bennett Keiryn L KL Superti-Furga Giulio G Henao-Mejia Jorge J Sutterwala Fayyaz S FS Williams Adam A Flavell Richard A RA Eisenbarth Stephanie C SC
Proceedings of the National Academy of Sciences of the United States of America 20150223 10
Dendritic cells (DCs) are the primary leukocytes responsible for priming T cells. To find and activate naïve T cells, DCs must migrate to lymph nodes, yet the cellular programs responsible for this key step remain unclear. DC migration to lymph nodes and the subsequent T-cell response are disrupted in a mouse we recently described lacking the NOD-like receptor NLRP10 (NLR family, pyrin domain containing 10); however, the mechanism by which this pattern recognition receptor governs DC migration r ...[more]