A genome-wide map of hyper-edited RNA reveals numerous new sites.
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ABSTRACT:
SUBMITTER: Porath HT
PROVIDER: S-EPMC4365171 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
A genome-wide map of hyper-edited RNA reveals numerous new sites.
Porath Hagit T HT Carmi Shai S Levanon Erez Y EY
Nature communications 20140827
Adenosine-to-inosine editing is one of the most frequent post-transcriptional modifications, manifested as A-to-G mismatches when comparing RNA sequences with their source DNA. Recently, a number of RNA-seq data sets have been screened for the presence of A-to-G editing, and hundreds of thousands of editing sites identified. Here we show that existing screens missed the majority of sites by ignoring reads with excessive ('hyper') editing that do not easily align to the genome. We show that caref ...[more]
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