Ontology highlight
ABSTRACT:
SUBMITTER: Gaedigk A
PROVIDER: S-EPMC4365394 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Gaedigk Andrea A Freeman Natalie N Hartshorne Toinette T Riffel Amanda K AK Irwin David D Bishop Jeffrey R JR Stein Mark A MA Newcorn Jeffrey H JH Jaime Lazara Karelia Montané LK Cherner Mariana M Leeder J Steven JS
Scientific reports 20150319
CYP2D6 contributes to the metabolism of many clinically used drugs and is increasingly tested to individualize drug therapy. The CYP2D6 gene is challenging to genotype due to the highly complex nature of its gene locus. TaqMan technology is widely used in the clinical and research settings for genotype analysis due to assay reliability, low cost, and the availability of commercially available assays. The assay identifying 1023C>T (rs28371706) defining a reduced function (CYP2D6*17) and several n ...[more]