Ontology highlight
ABSTRACT:
SUBMITTER: Ahmed U
PROVIDER: S-EPMC4365413 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Scientific reports 20150319
There is currently no biochemical test for detection of early-stage osteoarthritis (eOA). Tests for early-stage rheumatoid arthritis (eRA) such as rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) antibodies require refinement to improve clinical utility. We developed robust mass spectrometric methods to quantify citrullinated protein (CP) and free hydroxyproline in body fluids. We detected CP in the plasma of healthy subjects and surprisingly found that CP was increased in both ...[more]