Ontology highlight
ABSTRACT:
SUBMITTER: Cerasoli E
PROVIDER: S-EPMC4365737 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Frontiers in chemistry 20150319
Amyloid-beta (Aβ) peptide oligomers are believed to be the causative agents of Alzheimer's disease (AD). Though post-mortem examination shows that insoluble fibrils are deposited in the brains of AD patients in the form of intracellular (tangles) and extracellular (plaques) deposits, it has been observed that cognitive impairment is linked to synaptic dysfunction in the stages of the illness well before the appearance of these mature deposits. Increasing evidence suggests that the most toxic for ...[more]