Water permeation drives tumor cell migration in confined microenvironments.
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ABSTRACT:
SUBMITTER: Stroka KM
PROVIDER: S-EPMC4365996 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
Water permeation drives tumor cell migration in confined microenvironments.
Stroka Kimberly M KM Jiang Hongyuan H Chen Shih-Hsun SH Tong Ziqiu Z Wirtz Denis D Sun Sean X SX Konstantopoulos Konstantinos K
Cell 20140410 3
Cell migration is a critical process for diverse (patho)physiological phenomena. Intriguingly, cell migration through physically confined spaces can persist even when typical hallmarks of 2D planar migration, such as actin polymerization and myosin II-mediated contractility, are inhibited. Here, we present an integrated experimental and theoretical approach ("Osmotic Engine Model") and demonstrate that directed water permeation is a major mechanism of cell migration in confined microenvironments ...[more]
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