Restricted dog leucocyte antigen (DLA) class II haplotypes and genotypes in Beagles.
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ABSTRACT:
SUBMITTER: Soutter F
PROVIDER: S-EPMC4366010 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
Restricted dog leucocyte antigen (DLA) class II haplotypes and genotypes in Beagles.
Soutter Francesca F Kennedy Lorna J LJ Ollier William E R WE Solano-Gallego Laia L Catchpole Brian B
Veterinary journal (London, England : 1997) 20150105 3
Beagles are commonly used in vaccine trials as part of the regulatory approval process. Genetic restriction within this breed and the impact this might have on vaccine responses are rarely considered. This study was designed to characterise diversity of dog leucocyte antigen (DLA) class II genes in a breeding colony of laboratory Beagles, whose offspring are used in vaccine studies. DLA haplotypes were determined by PCR and sequence-based typing from genomic DNA extracted from blood. Breeding co ...[more]
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