Ontology highlight
ABSTRACT:
SUBMITTER: Kilpatrick K
PROVIDER: S-EPMC4366176 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Kilpatrick Kiri K Zeng Yimeng Y Hancock Tommy T Segatori Laura L
PloS one 20150319 3
Aggregation of α-synuclein (α-syn) is associated with the development of a number of neurodegenerative diseases, including Parkinson's disease (PD). The formation of α-syn aggregates results from aberrant accumulation of misfolded α-syn and insufficient or impaired activity of the two main intracellular protein degradation systems, namely the ubiquitin-proteasome system and the autophagy-lysosomal pathway. In this study, we investigated the role of transcription factor EB (TFEB), a master regula ...[more]