Dataset Information

Airway response to methacholine following eucapnic voluntary hyperpnea in athletes.

ABSTRACT:

Aim

To evaluate the changes in airway responsiveness to methacholine inhalation test (MIT) when performed after an eucapnic voluntary hyperpnea challenge (EVH) in athletes.

Methods

Two MIT preceded (visit 1) or not (visit 2) by an EVH, were performed in 28 athletes and 24 non-athletes. Twelve athletes and 13 non-athletes had airway hyperresponsiveness (AHR) to methacholine, and 11 athletes and 11 non-athletes had AHR to EVH (EVH+).

Results

The MIT PC20 post-EVH was significantly lower compared to baseline MIT PC20 by 1.3±0.7 doubling-concentrations in EVH+ athletes only (p<0.0001). No significant change was observed in EVH- athletes and EVH+/EVH- non-athletes. A significant correlation between the change in MIT PC20 post-EVH and EVH+/EVH- status and athlete/nonathlete status was found (Adjusted R2=0.26 and p<0.001). Three (11%) athletes and one (4%) non-athlete had a change in the diagnosis of AHR when MIT was performed consecutively to EVH.

Conclusion

The responsiveness to methacholine was increased by a previous indirect challenge in EVH+ athletes only. The mechanisms for such increase remain to be determined. MIT and EVH should ideally be performed on separate occasions as there is a small but possible risk to obtain a false-positive response to methacholine when performed immediately after the EVH.

Trial registration

ClinicalTrials.gov NCT00686491.

SUBMITTER: Bougault V

PROVIDER: S-EPMC4366214 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Publications

Airway response to methacholine following eucapnic voluntary hyperpnea in athletes.

Bougault Valérie V Blouin Evelyne E Turmel Julie J Boulet Louis-Philippe LP

PloS one 20150319 3

<h4>Aim</h4>To evaluate the changes in airway responsiveness to methacholine inhalation test (MIT) when performed after an eucapnic voluntary hyperpnea challenge (EVH) in athletes.<h4>Methods</h4>Two MIT preceded (visit 1) or not (visit 2) by an EVH, were performed in 28 athletes and 24 non-athletes. Twelve athletes and 13 non-athletes had airway hyperresponsiveness (AHR) to methacholine, and 11 athletes and 11 non-athletes had AHR to EVH (EVH+).<h4>Results</h4>The MIT PC20 post-EVH was signific ...[more]

PMID: 25789614

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Dataset Information

Airway response to methacholine following eucapnic voluntary hyperpnea in athletes.

Aim

Methods

Results

Conclusion

Trial registration

Publications

Airway response to methacholine following eucapnic voluntary hyperpnea in athletes.

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