Ontology highlight
ABSTRACT:
SUBMITTER: Landeta C
PROVIDER: S-EPMC4366281 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Nature chemical biology 20150216 4
In bacteria, disulfide bonds confer stability on many proteins exported to the cell envelope or beyond. These proteins include numerous bacterial virulence factors, and thus bacterial enzymes that promote disulfide bond formation represent targets for compounds inhibiting bacterial virulence. Here, we describe a new target- and cell-based screening methodology for identifying compounds that inhibit the disulfide bond-forming enzymes Escherichia coli DsbB (EcDsbB) or Mycobacterium tuberculosis VK ...[more]