Ontology highlight
ABSTRACT:
SUBMITTER: McCallister C
PROVIDER: S-EPMC4366816 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
McCallister Chelsea C Siracusa Matthew C MC Shirazi Farzaneh F Chalkia Dimitra D Nikolaidis Nikolas N
Scientific reports 20150320
A fundamental question in molecular evolution is how protein functional differentiation alters the ability of cells and organisms to cope with stress and survive. To answer this question we used two paralogous Hsp70s from mouse and explored whether these highly similar cytosolic molecular chaperones, which apart their temporal expression have been considered functionally interchangeable, are differentiated with respect to their lipid-binding function. We demonstrate that the two proteins bind to ...[more]