Ontology highlight
ABSTRACT:
SUBMITTER: Villaruz LC
PROVIDER: S-EPMC4367610 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Villaruz Liza C LC Kalyan Aparna A Zarour Hassane H Socinski Mark A MA
Translational lung cancer research 20140201 1
Immunotherapy has emerged in recent years as a promising therapeutic approach in lung cancer. Two approaches are of particular interest: immune checkpoint inhibition, which aims to counteract the physiologic mechanisms of immune tolerance co-opted by some tumors, and vaccine therapy, which enables enhanced exposure to tumor antigen. Immune checkpoint therapies include the monoclonal antibody blockade of the cytotoxic T-lymphocyte antigen-4 (CTLA-4) with ipilimumab, as well as antibody blockade o ...[more]