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Progress and future aspects in genetics of human hypertension.

ABSTRACT: Hypertension has become a major global health burden due to its high prevalence and associated increase in risk of cardiovascular disease and premature death. It is well established that hypertension is determined by both genetic and environmental factors and their complex interactions. Recent large-scale meta-analyses of genome-wide association studies (GWAS) have successfully identified a total of 38 loci which achieved genome-wide significance (P?

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC4368442 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Progress and future aspects in genetics of human hypertension.

Zhao Qi Q   Kelly Tanika N TN   Li Changwei C   He Jiang J  

Current hypertension reports 20131201 6

Hypertension has become a major global health burden due to its high prevalence and associated increase in risk of cardiovascular disease and premature death. It is well established that hypertension is determined by both genetic and environmental factors and their complex interactions. Recent large-scale meta-analyses of genome-wide association studies (GWAS) have successfully identified a total of 38 loci which achieved genome-wide significance (P < 5 × 10(-8)) for their association with blood  ...[more]

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