HDAC4, a prognostic and chromosomal instability marker, refines the predictive value of MGMT promoter methylation.

ABSTRACT: Chromosomal instability is a hallmark of human cancers and is closely linked to tumorigenesis. The prognostic value of molecular signatures of chromosomal instability (CIN) has been validated in various cancers. However, few studies have examined the relationship between CIN and glioma. Histone deacetylases (HDACs) regulate chromosome structure and are linked to the loss of genomic integrity in cancer cells. In this study, the prognostic value of HDAC4 expression and its association with markers of CIN were investigated by analyzing data from our own and four other large sample databases. The results showed that HDAC4 expression is downregulated in high- as compared to low-grade glioma and is associated with a favorable clinical outcome. HDAC4 expression and CIN were closely related in gli

SUBMITTER: Cheng W 

PROVIDER: S-EPMC4368847 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature