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A randomized controlled trial of brief and ultrabrief pulse right unilateral electroconvulsive therapy.


ABSTRACT: BACKGROUND:Some studies suggest better overall outcomes when right unilateral electroconvulsive therapy (RUL ECT) is given with an ultrabrief, rather than brief, pulse width. METHODS:The aim of the study was to test if ultrabrief-pulse RUL ECT results in less cognitive side effects than brief- pulse RUL ECT, when given at doses which achieve comparable efficacy. One hundred and two participants were assigned to receive ultrabrief (at 8 times seizure threshold) or brief (at 5 times seizure threshold) pulse RUL ECT in a double-blind, randomized controlled trial. Blinded raters assessed mood and cognitive functioning over the ECT course. RESULTS:Efficacy outcomes were not found to be significantly different. The ultrabrief group showed less cognitive impairment immediately after a single session of ECT, and over the treatment course (autobiographical memory, orientation). CONCLUSIONS:In summary, when ultrabrief RUL ECT was given at a higher dosage than brief RUL ECT (8 versus 5 times seizure threshold), efficacy was comparable while cognitive impairment was less.

SUBMITTER: Loo CK 

PROVIDER: S-EPMC4368876 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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A randomized controlled trial of brief and ultrabrief pulse right unilateral electroconvulsive therapy.

Loo Colleen K CK   Katalinic Natalie N   Smith Deirdre J DJ   Ingram Anna A   Dowling Nathan N   Martin Donel D   Addison Kerryn K   Hadzi-Pavlovic Dusan D   Simpson Brett B   Schweitzer Isaac I  

The international journal of neuropsychopharmacology 20141205 1


<h4>Background</h4>Some studies suggest better overall outcomes when right unilateral electroconvulsive therapy (RUL ECT) is given with an ultrabrief, rather than brief, pulse width.<h4>Methods</h4>The aim of the study was to test if ultrabrief-pulse RUL ECT results in less cognitive side effects than brief- pulse RUL ECT, when given at doses which achieve comparable efficacy. One hundred and two participants were assigned to receive ultrabrief (at 8 times seizure threshold) or brief (at 5 times  ...[more]

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