Unknown

Dataset Information

0

Emerging therapeutic targets of sepsis-associated acute kidney injury.


ABSTRACT: Sepsis-associated acute kidney injury (SA-AKI) is linked to high morbidity and mortality. To date, singular approaches to target specific pathways known to contribute to the pathogenesis of SA-AKI have failed. Because of the complexity of the pathogenesis of SA-AKI, a reassessment necessitates integrative approaches to therapeutics of SA-AKI that include general supportive therapies such as the use of vasopressors, fluids, antimicrobials, and target-specific and time-dependent therapeutics. There has been recent progress in our understanding of the pathogenesis and treatment of SA-AKI including the temporal nature of proinflammatory and anti-inflammatory processes. In this review, we discuss the clinical and experimental basis of emerging therapeutic approaches that focus on targeting early proinflammatory and late anti-inflammatory processes, as well as therapeutics that may enhance cellular survival and recovery. Finally, we include ongoing clinical trials in sepsis.

SUBMITTER: Swaminathan S 

PROVIDER: S-EPMC4369320 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Emerging therapeutic targets of sepsis-associated acute kidney injury.

Swaminathan Sundararaman S   Rosner Mitchell H MH   Okusa Mark D MD  

Seminars in nephrology 20150101 1


Sepsis-associated acute kidney injury (SA-AKI) is linked to high morbidity and mortality. To date, singular approaches to target specific pathways known to contribute to the pathogenesis of SA-AKI have failed. Because of the complexity of the pathogenesis of SA-AKI, a reassessment necessitates integrative approaches to therapeutics of SA-AKI that include general supportive therapies such as the use of vasopressors, fluids, antimicrobials, and target-specific and time-dependent therapeutics. Ther  ...[more]

Similar Datasets

| S-EPMC6913588 | biostudies-literature
| S-EPMC7485311 | biostudies-literature
| S-EPMC8052759 | biostudies-literature
| S-EPMC7063889 | biostudies-literature
2023-12-31 | GSE225193 | GEO
| S-EPMC7270721 | biostudies-literature
| S-EPMC7556522 | biostudies-literature
| S-EPMC6743337 | biostudies-literature
| S-EPMC8279954 | biostudies-literature
| S-EPMC7290350 | biostudies-literature