Ontology highlight
ABSTRACT:
SUBMITTER: Bastos de Oliveira FM
PROVIDER: S-EPMC4369404 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Molecular cell 20150305 6
The Mec1/Tel1 kinases (human ATR/ATM) play numerous roles in the DNA replication stress response. Despite the multi-functionality of these kinases, studies of their in vivo action have mostly relied on a few well-established substrates. Here we employed a combined genetic-phosphoproteomic approach to monitor Mec1/Tel1 signaling in a systematic, unbiased, and quantitative manner. Unexpectedly, we find that Mec1 is highly active during normal DNA replication, at levels comparable or higher than Me ...[more]